The antibiotic from the penicillin group - Shorter University


Amoxil is the trade name for an antibiotic from the penicillin group, the active ingredient of which is Amoxicillin.

Amoxicillin is one of the most popular and effective antibacterial bactericidal drugs, with which many bacterial infections have been successfully treated for half a century.
This antibiotic was developed in 1972 by specialists from the British pharmaceutical company Beecham. It is still relevant today. According to WHO, amoxicillin is included in the list of drugs that are mandatory for use in the health care system of any country.

Amoxicillin is an aminobenzyl penicillin, whose bactericidal action occurs as a result of inhibition of bacterial cell wall synthesis. As a result, the growth of pathogenic microflora slows down, which leads to the rapid death of pathogens. Thresholds for minimum effective concentrations vary for different susceptible organisms. For example, Enterobacteriaceae are considered susceptible when taking amocicillin at a concentration of 8 mg/ml and resistant at a concentration more or equivalent to 32 mg/ml.

Drug Name: Amoxil
Tablet Strength: 500 mg, 250 mg
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What Is Amoxil Used for?

Amoxil is a broad-spectrum antibiotic. It is used in the treatment of various infections that affect various organs and systems of the body. As a rule, this drug is effective for the treatment of infectious diseases caused by the development of streptococci. Among the most common diseases that streptococci lead to are the following:

  • infections of the upper respiratory tract and ENT organs (otitis media, sinusitis, tonsillitis, frontal sinusitis);
  • bacterial diseases of the lower respiratory tract (community-acquired pneumonia, acute bronchitis and chronic bronchitis, which has passed into the acute stage);
  • diseases of the kidneys and urinary tract (cystitis, pyelonephritis);
  • intestinal infections (enteritis, colitis);
  • infectious lesions of the skin and soft tissues (phlegmon, abscess, erysipelas).

In combination with metronidazole, Amoxil demonstrates efficacy in the treatment of chronic gastritis, as well as peptic ulcer of the stomach and duodenum.

In accordance with the data of numerous clinical studies, the probability of successful treatment of respiratory tract infections with this antibiotic is 90%. In other cases, bacteria are resistant to Amoxicillin.

It is important that Amoxil is also used as a prophylactic drug, which is unusual for an antibiotic. It is recommended to take it periodically for patients who have a high risk of endocarditis (a bacterial inflammation of the heart). This antibiotic is sometimes included in the medical arsenal of dentists, who recommend taking it during prosthetics, tooth extractions, and especially when installing implants.

The prevalence of resistant strains of various microorganisms varies geographically, so it is advisable to focus on local information on resistance when prescribing this antibiotic, especially when treating severe infections. With the prevalence of resistant strains at such a level that it becomes doubtful the appropriateness of using the drug, at least in the treatment of certain infections, it is better to seek the help of a specialist. It may be necessary to test the causative agent for sensitivity to Amoxicillin and to a number of other antibiotics so that the most effective drug can be identified.

Amoxil Side Effects

Like other antibiotics from the penicillin group, Amoxil can cause unpleasant side effects. Some of them are more characteristic and occur frequently, some rarely or in isolated cases.

From allergic reactions, urticaria, erythema, Quincke’s edema (especially if the patient is allergic to any other antibiotics), rhinitis, conjunctivitis can develop. Rarely, allergic symptoms such as fever, joint pain, eosinophilia are noted, in isolated cases anaphylactic shock is possible.

Effects associated with chemotherapeutic action: the development of superinfections is possible (especially in patients with chronic diseases or reduced body resistance). Colonization of resistant microorganisms or fungi is possible, for example, oral and vaginal candidiasis is a frequent complication of long-term use of Amoxil.

With prolonged use of Amoxil in high doses, phenomena such as dizziness, ataxia, confusion, depression, peripheral neuropathy, convulsions are possible. In patients with impaired liver function, a transient moderate increase in the level of liver enzymes may be recorded, rare cases of hepatitis and cholestatic jaundice have been noted.

The most common adverse reactions accompanying the use of Amoxil are discomfort, nausea, loss of appetite, vomiting, flatulence, loose stools, diarrhea, enanthems (especially on the oral mucosa), dry mouth and impaired taste perception (may seem to have changed habitual taste of foods, or they may seem tasteless). As a rule, the listed effects are characterized by mild severity and often disappear as therapy is continued or very quickly after its termination. The frequency of these complications can be reduced by taking amoxicillin with food. Avoid taking this antibiotic on an empty stomach.

Care should be taken when prescribing Amoxil together with metronidazole, because this combination of drugs leads to increased side effects from the antibiotic. Anorexia, severe diarrhea, constipation, epigastric pain, glossitis, stomatitis may develop, rarely hepatitis, pseudomembranous colitis, angioedema, interstitial nephritis, and impaired hematopoiesis. Patients receiving amoxicillin therapy in combination with metronidazole should be under the strict supervision of a doctor.

Predominantly, when used in combination with clavulanic acid, Amoxil can cause cholestatic jaundice, hepatitis, erythema multiforme, toxic epidermal necrolysis and exfoliative dermatitis.

Very rarely, taking Amoxicillin causes leukopenia, granulocytopenia, thrombocytopenia, pancytopenia, anemia, myelosuppression, agranulocytosis, prolongation of bleeding time and prothrombin time. All these changes are reversible and quickly disappear when therapy is stopped.

Reactions from the central nervous system are rare and include hyperkinesis, dizziness and convulsions. Convulsions are observed mainly in patients with renal insufficiency or in patients receiving high doses of the drug.

Amoxil Generic Name

Amoxil is the trade name for a branded antibiotic whose active ingredient is Amoxicillin and is manufactured in the United States by the pharmaceutical company USAantibiotics. This medicine, however, has many generics. Generics are medicines that are identical in composition to their branded prototype, that is, the chemical structure of a generic does not differ from the original medicine, except for the doses of active ingredients that may differ). Such preparations are also called complete. Complete analogues are drugs that contain identical active substances and similar forms of release.

Amoxicillin is available under different generic names, like Generic Amoxil, Amoxicillin, AmoxPlus, but the version under the name Trimox ia the most well-known among all generics, at least in the USA. It is manufactured by the Indian pharmaceutical company Mapra Laboratories Pvt. Ltd., located in Mumbai, India. This company has been operating since 1985, with its 37-year-old history being among the most respectable and longest acting drug businesses if this country.

Indian pharmaceutical corporations are among the largest in the world and they have a more than good reputation. Mapra Laboratories Pvt. Ltd. is no exception, its products are trusted all over the world. And trust is a worthy indicator, especially when it comes to such vital medicines as antibiotics, on which human life and health can directly depend. It cooperates with many major drug suppliers in Asian, European and American countries. Significantly, Mapra Laboratories has its own online pharmacy, which offers the company’s branded medicines at even more affordable prices than are usually available in other online pharmacies, not to mention conventional pharmacies. Taking into account the fact that all generics are in any case much cheaper than the original medicine, the patient has the opportunity to purchase the antibiotic Amoxicillin generic at a very attractive low price with delivery literally to any part in the world.

Amoxil 500 Dosage

500 milligrams in one tablet or capsule is the most common dosage of Amoxil for use in adults. There is also a 250 mg option, but this is mainly used to treat children and teenagers. Amoxil 500 mg oblong tablets are coated with a yellowish-white protective shell. Moreover, each tablet has a convenient dosing notch on each side, with which it can be neatly divided into two equal parts.

Instructions for the use of Amoxil states that adult patients, as well as children over 10 years old and weighing more than 40 kg, can take no more than 250-500 mg once. As a rule, this antibiotic is taken three times a day with an eight-hour interval. Thus, the Amoxil 500 mg variant is also great for treating children, since all that needs to be done is to split the tablet into two parts and give the child one half at a time. At the same time, the cost of an antibiotic in a dosage of 500 mg will be much lower than in the 250 mg version.

The duration of Amoxil therapy is determined by the doctor, it is recommended not to make this decision on your own. Sometimes, to monitor the effectiveness of treatment, it may be necessary to pass certain tests. In most cases, the duration of treatment is 7-10 days (but at least a minimum of 2-3 days after the symptoms disappear, so in severe cases it may be necessary to take an antibiotic for 14 days or even longer). In the treatment of infections caused by beta-hemolytic streptococcus, the course of treatment is at least 10 days to prevent late complications, such as rheumatism and glomerulonephritis, which can ruin the patient’s life for a long time, if not forever.

Buy Generic Amoxil Online

One of the most expensive groups of drugs are antibiotics. At the same time, there are not so many new antibiotics on the market. The newest antibiotic on the market (Linezolid) recently celebrated its 22nd anniversary. Not only does development and clinical research take decades, but each project to develop a new antibiotic is worth billions of dollars. In this regard, very few pharmaceutical companies in the US and Europe can conduct such expensive research.

Most other pharmaceutical companies produce generics, that is, analogues of well-known antibiotics, but under different trade names. The cost of such drugs is much lower than the cost of the original ones. So the generic Amoxil cost is usually at least two times lower than the cost of a branded drug, and in some cases, you can save up to 80% of the cost of a prototype drug on a purchase.

If the doctor prescribed you an expensive branded Amoxil, do not rush to buy it at the expense of your budget. Most likely, he has a cheaper analogue, which a pharmacist in a pharmacy can also advise you if you ask him about it. But the most profitable option would be to buy generic Amoxil online in one of the national, foreign or international online pharmacies. They offer the lowest prices, a large selection of manufacturers and the maximum choice of drug dosages.

Generic Amoxil OTC

Important! In this section, we touch upon such an issue as the purchase of a generic Amoxil without a doctor’s prescription. This doesn’t mean that we urge you to prescribe this medicine yourself, as it is an antibiotic with a serious effect on the body. However, situations are not uncommon when there is no doctor’s prescription at hand, but the medicine is needed. For example, if you already know the disease against which the doctor prescribed Amoxil for you, but now you don’t have the opportunity or the strength to go for a prescription. Also, the option of buying generic Amoxil without a prescription is suitable for those patients who have received a positive test for the sensitivity of the pathogen to this antibiotic, but they don’t have a prescription. In these situations, you can safely purchase the generic Amoxil other the counter (otc). The easiest way to do this is online, and you should look at pharmacies based outside the US, because countries like India or Canada (major suppliers of Amoxil generics) have much more relaxed pharmaceutical laws, and the likelihood that a prescription will be required from you is minimal.